منابع مشابه
The role of ABC transporters in anticancer drug transport
* Correspondence: [email protected]
متن کاملHow do ABC transporters drive transport?
Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins that hydrolyze ATP to drive transport. In the last two decades these proteins have been extensively characterized on a genetic and biochemical level, and in recent years high-resolution crystal structures of several nucleotide-binding domains and full-length transporters have extended our knowledge. Here we dis...
متن کامل[Pleiotropic drug resistance ABC transporters in fungi].
Overexpression of pleiotropic drug resistance (PDR) efflux pumps of the ATP-binding cassette (ABC) transporter superfamily is the major cause of fungal multi-drug resistance and decreased efficacy of antifungal drugs. This review focused on recent progresses in understanding of the PDR efflux pumps of ABC transporter superfamily in Saccharomyces cerevisiae and the fungal pathogens Candida albic...
متن کاملThe role of ABCG-type ABC transporters in phytohormone transport
Plant hormones (phytohormones) integrate endogenous and exogenous signals thus synchronizing plant growth with environmental and developmental changes. Similar to animals, phytohormones have distinct source and target tissues, hence controlled transport and focused targeting are required for their functions. Many evidences accumulated in the last years about the regulation of long-distance and ...
متن کاملABC transporters of Fasciola hepatica as putative drug targets
Background The liver fluke Fasciola hepatica is one of the most important parasites affecting animal health all over the world, causing the so called liver fluke disease (fascioliosis). Although infections of humans are rather rare in most western countries, several million people worldwide are infected by this trematode. Beside its threat to humans the infection of animal stock leads to large ...
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ژورنال
عنوان ژورنال: Journal of Korean Society for Clinical Pharmacology and Therapeutics
سال: 2003
ISSN: 1225-5467
DOI: 10.12793/jkscpt.2003.11.2.80